Homeostatic synaptic plasticity and neurological diseases
10.3760/cma.j.cn115354-20220108-00014
- VernacularTitle:稳态突触可塑性与神经系统疾病
- Author:
Luyu HU
1
;
Zheman XIAO
Author Information
1. 武汉大学人民医院神经内科，武汉 430060
- Keywords:
Synaptic homeostasis;
Plasticity;
Neurological disease;
Presynaptic regulation;
Synaptic scaling
- From:
Chinese Journal of Neuromedicine
2022;21(4):403-408
- CountryChina
- Language:Chinese
-
Abstract:
Homeostatic synaptic plasticity is an important negative feedback regulation mechanism that maintains the functional stability of the nervous system, acting by regulating the release of presynaptic neurotransmitters or interfering with the synthesis of postsynaptic receptors. A series of studies have demonstrated strong links between homeostatic synaptic plasticity and a variety of seemingly disparate neurological and psychiatric disorders, including autism spectrum disorder, intellectual disability, schizophrenia, fragile X syndrome, etc. In-depth understanding of homeostatic synaptic plasticity at cellular and molecular levels may help finding new targets and therapies for treatment of these related diseases. In this review, we explore the possible mechanisms of synaptic homeostasis regulatory system in neurological diseases as follows.
