Comparison of P300 and serum FGF22 levels between cognitive impairment patients with first-episode and recurrent depression and their relations with cognitive function and serum inflammatory factors
10.3760/cma.j.cn115354-20211108-00720
- VernacularTitle:首发性和复发性抑郁症伴认知功能障碍患者P300、血清FGF22水平的比较及其与认知功能、血清炎性因子的关系
- Author:
Yuhao XU
1
;
Wei HAN
;
Jianhui XU
;
Wenli ZHU
;
Ming YU
Author Information
1. 江苏大学附属医院神经内科，镇江 212001
- Keywords:
First-episode depression;
Recurrent depression;
Cognitive impairment;
P300;
Fibroblast growth factor 22
- From:
Chinese Journal of Neuromedicine
2022;21(4):354-358
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the differences of event-related potential P300 and serum fibroblast growth factor 22 (FGF22) levels in cognitive impairment patients with first-episode and recurrent depression, and analyze the relations of each index with cognitive function and serum inflammatory factors.Methods:From June 2020 to April 2021, 45 cognitive impairment patients with first-episode depression (first-episode group) and 42 cognitive impairment patients with recurrent depression (recurrence group) were selected from our hospital. P300 examination was performed and serum FGF22, interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) levels were measured by enzyme-linked immunosorbent experiment (ELISA). The differences in clinical data, P300 examination results, and serum FGF22, IL-6 and TNF-α levels were compared between the two groups. The correlations of P300 amplitude and latency and serum FGF22 level with Montreal Cognitive Assessment (MoCA) scores and IL-6 and TNF-α levels were analyzed.Results:As compared with the first-episode group, the recurrence group had significantly decreased MoCA scores, P300 amplitude and serum FGF22 level, and statistically increased P300 latency and IL-6 and TNF-α levels ( P<0.05). Correlation analysis showed that P300 amplitude and serum FGF22 level were positively correlated with MoCA scores, and negatively correlated with IL-6 and TNF-α levels ( P<0.05); P300 latency was negatively correlated with MoCA scores, and positively correlated with IL-6 and TNF-α levels ( P<0.05). Conclusion:P300 amplitude and latency and serum FGF22 level are different between cognitive impairment patients with first-episode and recurrent depression, and they are correlated with the cognitive function and serum inflammatory factors.
