Beneficial effects and mechanisms of regular exercise on chronic traumatic encephalopathy
10.3760/cma.j.cn115354-20210618-00387
- VernacularTitle:规律运动对慢性创伤性脑病的改善效应及其机制
- Author:
Weicheng CHEN
1
;
Kaiyu CAI
;
Junhan CHEN
;
Yujing LI
;
Wenqi LYU
;
Xiangrong CHEN
Author Information
1. 福建医科大学附属第二医院、第二临床医学院神经外科，泉州 362000
- Keywords:
Sports trauma;
Chronic traumatic encephalopathy;
Neurodegeneration;
Sports rehabilitation;
Regular exercise
- From:
Chinese Journal of Neuromedicine
2022;21(3):305-311
- CountryChina
- Language:Chinese
-
Abstract:
Physical exercise can accompany with risks, such as repeated blows to the head, causing mild traumatic brain injury (mTBI), and mTBI will cause continuous cognitive, behavioral and mental problems, bring neurodegeneration and ultimately lead to chronic traumatic encephalopathy (CTE). However, this regular exercise can also be used as a neuroprotective agent against cognitive decline in the brain and affect the plasticity of the brain. Regular exercise can improve the brain learning, memory, recognition and the disease process of CTE by reducing abnormal protein accumulation, promoting neurogenesis, synapse formation, increasing synaptic plasticity and angiogenesis, improving microcirculation, anti-microinflammation and oxidative stress, and promoting mental health. This review analyzes the pathological changes and mechanism of CTE and explore the mechanism of regular exercise in improving neurological function after CTE, so as to provide new ideas for CTE rehabilitation.
