Recent advance in role of DNA methylation in classification and diagnosis of central nervous system tumors
10.3760/cma.j.cn115354-20210414-00244
- VernacularTitle:DNA甲基化在中枢神经系统肿瘤分型及诊断中的应用进展
- Author:
Rong GE
1
;
Jinping CHEN
;
Chuangfeng LIU
Author Information
1. 宁波市临床病理诊断中心组织病理科，宁波 315021
- Keywords:
DNA methylation;
Central nervous system;
Tumor;
Molecular classification;
Pathological diagnosis
- From:
Chinese Journal of Neuromedicine
2022;21(3):294-298
- CountryChina
- Language:Chinese
-
Abstract:
DNA methylation is an epigenetic modification form with the most extensive and in-depth studying. DNA methylation is a powerful tool for tumor classification in the central nervous system (CNS), which is used in the molecular classification of various tumors, such as ependyma and meningioma, to accurately predict tumor biological behavior and survival prognosis, and to provide important information for individualized treatment. DNA methylation will also become an important auxiliary diagnostic method for the identification of different types of CNS tumors, improve the accuracy of pathological diagnosis, and even help to find new tumor entities. In the current review, we focus on the role of DNA methylation in the molecular classification and pathological diagnosis of CNS tumors, in order to provide more enlightenment for accurate diagnoses and treatments of tumors.
