Recent advance in role of immune system in pathogenesis of Alzheimer's disease and its immunotherapies
10.3760/cma.j.cn115354-20210925-00627
- VernacularTitle:阿尔茨海默病的免疫发病机制及免疫治疗研究新进展
- Author:
Xijuan JIANG
1
;
Linli XU
;
Xiangfei MENG
Author Information
1. 临沂市中医医院脑病科，临沂 276003
- Keywords:
Alzheimer's disease;
Immunological mechanism;
Immunotherapy;
Neuroinflammation
- From:
Chinese Journal of Neuromedicine
2022;21(2):200-206
- CountryChina
- Language:Chinese
-
Abstract:
The amyloid plaques (Aβ) hypotheses and Tau propagation hypothesis are still proposed as the most prevailing causes for Alzheimer's disease (AD). Recent compelling evidences have firmly demonstrated that there are tight involvements of dysfunction of the immune system in the pathogenesis and progression of AD. Here, we review the current knowledge on the role of immune system in pathogenesis of AD and discuss the most relevant findings in immunotherapies for AD to help clinician to further consider the possible direction of diagnosis and treatment of AD.
