Recent advance in ubiquitin-proteasome system and TAR DNA/RNA-binding domain protein-43 in treatment of Alzheimer's disease

VernacularTitle:泛素-蛋白酶体系统及TDP-43在阿尔茨海默病治疗中的研究进展
Author: Pan HE ¹ ; Zhisheng BA ; Nanqu HUANG ; Yuanyuan LI ; Yong LUO
Author Information

1. 遵义医科大学第三附属医院（遵义市第一人民医院）神经内科，遵义　563000
Keywords: TAR DNA/RNA-binding domain protein 43; Ubiquitin-proteasome system; Alzheimer's disease
From: Chinese Journal of Neuromedicine 2022;21(2):195-199
CountryChina
Language:Chinese
Abstract: TAR DNA/RNA-binding domain protein 43 (TDP-43) has become one of the pathogenic factors of many neurodegenerative diseases, such as Alzheimer's disease (AD). Clearance of abnormal accumulation of TDP-43 might be the potential treatment target in AD patients. Ubiquitin-proteasome system (UPS) is one of the main ways of protein clearance. UPS dysfunction plays an important role in the pathogenesis and progression of AD. This review focuses on the roles of TDP-43 and UPS in the pathogenesis of AD, as well as the research progress of UPS mediated clearance TDP-43 in the treatment of AD.