Recent advance in role of galectin-3 in central neurodegenerative diseases
10.3760/cma.j.cn115354-20210111-00022
- VernacularTitle:Gal3在中枢神经系统退行性疾病中的作用研究进展
- Author:
Zhongyu FAN
1
;
Xunyao HOU
;
Xueping LIU
;
Qingqing YIN
Author Information
1. 山东第一医科大学附属省立医院老年神经内科，济南 250021
- Keywords:
Galectin-3;
Central neurodegenerative disease;
Alzheimer's disease;
Parkinson's disease;
Huntington disease
- From:
Chinese Journal of Neuromedicine
2022;21(2):183-188
- CountryChina
- Language:Chinese
-
Abstract:
Galectin-3 (Gal3) is a multipotent protein involved in cell activation, proliferation and migration, which plays an important role in a variety of physiological and pathological processes. Recent studies have shown that Gal3 plays an important role in the pathogenesis of central nervous system degenerative diseases, but its specific mechanism is not clear. This article reviews the research progress on the mechanism and expression of Gal3 in central nervous system degenerative diseases, and discusses the application value of Gal3 as a new therapeutic target in central nervous system degenerative diseases, so as to provide new scientific basis for early prevention and treatment of central nervous system degenerative diseases.
