Recent advance in calcium-regulated autophagy in neurodegenerative diseases
10.3760/cma.j.cn115354-20201231-01013
- VernacularTitle:钙调控自噬在神经退行性疾病中的研究进展
- Author:
Zhixiao ZHANG
1
;
Xiaofang LIU
;
Li WANG
Author Information
1. 山西医科大学附属第二医院神经内科，太原 030000
- Keywords:
Ca 2+;
Calcium storage compartment;
Calcium channel;
Autophagy;
Neurodegenerative disease
- From:
Chinese Journal of Neuromedicine
2022;21(1):81-86
- CountryChina
- Language:Chinese
-
Abstract:
Imbalance of calcium homeostasis and abnormal autophagy are important pathogenesis mechanisms for neurodegenerative diseases, as PD, AD, and amyotrophic lateral sclerosis (ALS); and correlation is noted between imbalance of calcium homeostasis and abnormal autophagy. A number of studies have reported that different calcium storage compartments of cells can affect autophagy via calcium channels or Ca 2+-related signal proteins, such as cytoplasm calcium release-activated calcium modulator 1 (Orai1) and transient receptor potential canonical channel (TRPC), endoplasmic reticulum calcium channel inositol 1,4,5-triphosphate receptor (IP3R), mitochondrial calcium uniporter (MCU) related to Ca 2+ uptake, lysosomal calcium channel transient receptor potential channel mucolipin 1(TRPML1) and two-pore channels, cytoplasmic Ca 2+/calmodulin-dependent kinase kinase β (CaMKKβ)/AMP-activated protein kinase(AMPK) pathway. This review summarizes the research progress on autophagy regulated by Ca 2+ in intracellular calcium storage compartments and cytoplasm in neurodegenerative diseases, with a view to further understand the pathogenesis of these diseases.
