Brain functions of patients with type 2 diabetes comorbid depression: a study based on resting-state fractional amplitude of low-frequency fluctuations
10.3760/cma.j.cn115354-20210714-00438
- VernacularTitle:基于静息态比率低频振幅的2型糖尿病共病抑郁的脑功能研究
- Author:
Jing TIAN
1
;
Lianping ZHAO
;
Ruifang LIU
;
Yashan LU
;
Gang HUANG
;
Juxiang LIU
;
Fengli LIANG
;
Yanyan GAO
;
Wenwen ZHANG
Author Information
1. 甘肃中医药大学第一临床医学院（甘肃省人民医院），兰州 730000
- Keywords:
Diabetes mellitus, type 2;
Magnetic resonance imaging;
Brain damage, chronic;
Depression
- From:
Chinese Journal of Neuromedicine
2022;21(1):34-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the abnormal patterns of spontaneous neural activity of patients with type 2 diabetes comorbid depression (T2DD) by using resting-state functional magnetic resonance imaging (rs-fMRI) fractional amplitude of low-frequency (fALFF) analysis, and determine the neuroimaging features of brain damage in T2DD patients.Methods:A perspective study was performed. Fifty-nine type 2 diabetes mellitus (T2DM) patients and 52 T2DD patients, admitted to and accepted treatment in Department of Endocrinology of our hospital from November 2017 to November 2020, were chosen; another 57 healthy controls matched with gender, age and education level, admitted to our hospital at the same time period were enrolled. Their clinical data, neuropsychological test and rs-fMRI data were collected; whole brain fALFF values were calculated, and fALFF values of different brain regions were compared in subjects of the 3 groups. Pearson correlation analysis was used to verify the correlations of fALFF values with clinical variables and neuropsychological scale scores.Results:The fALFF values in bilateral precuneus showed significant difference among the three groups ( P<0.05). The fALFF values in bilateral precuneus of the T2DD and T2DM groups were significantly lower than those in heathy control group ( P<0.05), and those in the T2DD group were lower than those in the T2DM group without significant difference ( P>0.05). Pearson correlation analysis showed that there were no correlations of fALFF values with clinical data and psychometric scale scores in T2DD group and T2DM group ( P>0.05). Conclusion:The abnormal patterns of spontaneous brain activity in the bilateral precuneus may be the neuroimaging markers of brain damage in T2DD patients.
