Correlations of micro-calcification load in carotid plaques and plaque vulnerability scores with 18F-sodium fluoride uptake ratio in PET-CT
10.3760/cma.j.cn115354-20210823-00534
- VernacularTitle:颈动脉斑块微钙化负荷及易损性评分与PET-CT检查中 18F-氟化钠吸收率的相关性分析
- Author:
Jianrong YAO
1
;
Jia DING
;
Xiaoliang SHAO
;
Ying HE
;
Song YANG
;
Xuegan LIAN
Author Information
1. 苏州大学附属第三医院神经内科，常州 213003
- Keywords:
Carotid;
Plaque;
Micro-calcification;
Ultrasound;
Positron emission tomography-computed tomography;
Vulnerability
- From:
Chinese Journal of Neuromedicine
2021;20(12):1254-1257
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlations of micro-calcification load in carotid plaques and plaque vulnerability scores detected by Micropure? ultrasonic technology with 18F-sodium fluoride ( 18F-NaF) uptake ratio (tissue-background ratio [TBR]) in positron emission tomography-computed tomography (PET-CT). Methods:Baseline data of patients with carotid atherosclerotic plaques admitted to our hospital from March 2017 to November 2020 were collected. Carotid arteries of these patients simultaneously positive on Micropure? ultrasound examination and 18F-NaF PET-CT were included. The number of spots in carotid plaques detected by Micropure? ultrasonic technology was defined as load of micro-calcification: they were divided into large number of micro-calcifications group (≥5 spots) and small number of micro-calcifications group (1-4 spots). The scores of carotid plaque vulnerability were evaluated according to carotid atherosclerosis scores in Diagnostic Value of Carotid Atherosclerosis Score for Ischemic Stroke. Correlations of TBR with micro-calcification load and plaque vulnerability scores in these 39 carotid arteries were analyzed. Results:Thirty-nine carotid arteries from 28 patients were enrolled: 24 carotid arteries were classified into the large number of micro-calcifications group and 15 carotid arteries were classified into the small number of micro-calcifications group. TBR of the large number of micro-calcifications group (2.61±0.73) was significantly increased as cpmpared with that of the small number of micro-calcifications group (1.93±0.43, t=-3.657, P=0.001). In the 39 carotid arteries, micro-calcification load was 5(3, 5), while the carotid plaque vulnerability scores were 2 (2, 3); micro-calcification load was positively correlated with TBR (2.35±0.71, r s=0.519, P=0.001), but no correlation was noted between TBR and carotid plaque vulnerability scores ( r s=0.086, P=0.602). Conclusion:Carotid plaque micro-calcification load detected by Micropure? ultrasound examination is associated with 18F-NaF uptake ratio; the larger the micro-calcification load, the more obvious the uptake of 18F-NaF.
