Recent advance in role of long non-coding RNA mediated competing endogenous RNA regulatory network in ischemic stroke
10.3760/cma.j.cn115354-20210111-00023
- VernacularTitle:lncRNA介导ceRNA调控网络作用于缺血性脑卒中的研究进展
- Author:
Jiqing ZHENG
1
;
Yun LIU
;
Yaobin LONG
;
Shijie LIAO
;
Boxiang LI
;
Xiangde LI
Author Information
1. 广西医科大学第二附属医院康复医学科，南宁 530007
- Keywords:
Ischemic stroke;
Long non-coding RNA;
Competing endogenous RNA;
Micro RNA
- From:
Chinese Journal of Neuromedicine
2021;20(11):1160-1166
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke (IS) is a kind of cerebrovascular disease caused by temporary or permanent decrease in local cerebral blood flow. The research of this disease by revealing its pathophysiological process and exploring new therapeutic targets from the cellular and molecular levels has always been the hot spot. In recent years, the competing endogenous RNA (ceRNA) regulatory network mediated by long non-coding RNA (lncRNA) has been proved to play a key role in the pathology and physiology of IS, which can effectively improve the diagnosis, treatment and prognosis of IS. This article aims to describe the mechanism of micro RNA (miRNA) and lncRNA in IS and the role of lncRNA as miRNA's ceRNA in the cell apoptosis, cell viability, angiogenesis, inflammatory response, oxidative stress, and neuroprotection of IS patients, in order to broaden the vision of the occurrence and development of IS and provide new ideas for its diagnosis and treatment.
