Clinical value of free-talk language functional cortex mapping methods based on high frequency response in epileptogenic focus resection
10.3760/cma.j.cn115354-20210630-00409
- VernacularTitle:基于高频响应的自由对话式皮层语言功能区定位方法在致痫灶切除术中的临床价值分析
- Author:
Xin GAO
1
;
Xiaoxia ZHOU
;
Jianbin WEN
;
Tianyi ZHOU
;
Duanyu NI
;
Liang QIAO
;
Xueyuan WANG
;
Xiaohua ZHANG
;
Xiaoli LI
;
Tao YU
Author Information
1. 首都医科大学宣武医院功能神经外科，北京功能神经外科研究所 100053
- Keywords:
Epilepsy;
Language mapping;
Free-talk approach based on high frequency response;
Electrical cortical stimulation
- From:
Chinese Journal of Neuromedicine
2021;20(10):989-995
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical value of free-talk language functional cortex mapping methods based on high frequency response in epileptic foci resection.Methods:Twenty patients with intractable epilepsy admitted to our hospital from January 2016 to May 2019 were chosen in our study. According to the different intraoperative mapping methods of language functional region, these patients were divided into test group ( n=10, using free-talk language function localization based on high frequency response [new method]+ electrical cortical stimulation [ECS]) and control group ( n=10, using ECS localization only). The overlap rate of the two methods in the test group were calculated and the postoperative follow-up results of patients in the two groups were analyzed. Results:In 10 patients from the test group, 33 positive loci in the Broca's area and 33 positive loci in the Wernicke's area were detected by new method; at the meantime, 16 positive loci in the Broca's area and 8 positive loci in the Wernicke's area were detected by ECS method, which had a overlap rate of 93.75% (15/16) in the Broca's area and 75.00% (6/8) in the Wernicke's area, respectively, as compared with the new method. In the 10 patients from the control group, 18 positive loci in the Broca's area and 3 positive loci in the Wernicke's area were detected by ECS method. In the test group, 7 patients achieved Engel grading I and 2 patients developed transient language function impairment after surgery; while in the control group, 5 patients achieved Engel grading I and 4 patients developed transient language function impairment after surgery.Conclusion:The new method has a high overlap rate with ECS method; the combination of the two methods can help to decrease the speech function impairment after excision of epileptogenic foci in patients with epilepsy.
