Recent advance in Spadin and its analogs in treatment of post-stroke depression
10.3760/cma.j.cn115354-20210123-00054
- VernacularTitle:Spadin及其类似物治疗脑卒中后抑郁的研究进展
- Author:
Xiuli WANG
1
;
Wei WEI
;
Cui FANG
;
Mengyao ZHANG
;
Fuping SHI
Author Information
1. 河北大学附属医院神经内科，保定 071000
- Keywords:
Post-stroke depression;
Spadin;
Spadin analog;
TREK-1
- From:
Chinese Journal of Neuromedicine
2021;20(9):956-959
- CountryChina
- Language:Chinese
-
Abstract:
Post-stroke depression (PSD) is one kind of the common mental diseases after stroke, and the prevention and treatment of PSD are very difficult. TREK-1, a two-pore domain potassium channel, is an important target in the pathogenesis of stroke and PSD, and it is closely related to neuroprotection and emotion regulation; inhibition of activity of TREK-1 channel can exert significant antidepressant effect. In recent years, TREK-1 channel blocker Spadin and Spadin analogs are discovered, and they have a relatively significant effect on ischemic stroke and PSD. In this paper, the research progress on the discovery, efficacy and therapeutic value of Spadin and Spadin analogs in PSD are summarized as follows.
