The Effect of Intravitreal Bevacizumab in Patients with Acute Central Serous Chorioretinopathy.
10.3341/kjo.2010.24.3.155
- Author:
Ji Won LIM
1
;
Su Jeong RYU
;
Min Cheol SHIN
Author Information
1. Department of Ophthalmology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea. jiwoneye@hallym.or.kr
- Publication Type:Original Article ; Comparative Study ; Randomized Controlled Trial
- Keywords:
Bevacizumab;
Central serous chorioretinopathy;
Randomized comparison;
Therapeutics
- MeSH:
Acute Disease;
Adult;
Antibodies, Monoclonal/*administration & dosage;
Capillary Permeability/drug effects;
Central Serous Chorioretinopathy/*drug therapy/physiopathology;
Female;
Follow-Up Studies;
Humans;
Injections, Intraocular;
Male;
Middle Aged;
Treatment Failure;
Vascular Endothelial Growth Factor A/*antagonists & inhibitors;
Visual Acuity/drug effects;
Vitreous Body
- From:Korean Journal of Ophthalmology
2010;24(3):155-158
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate the effect of intravitreal bevacizumab injection (IVBI) in acute central serous chorioretinopathy (CSC) patients. METHODS: Patients with acute CSC received IVBI (1.25 mg/0.05 mL) or observation by randomization. Twelve eyes in each group completed 6 months of regular follow-up and were ultimately included in this study. Each patient was assessed using best corrected visual acuity measurements, fluorescein angiography, and optical coherence tomography at baseline and had regular follow-ups after treatment. RESULTS: All patients showed improvements in visual acuity and fluorescein angiographic leakage and had resolution of their neurosensory detachment following treatment. There were no significant differences in visual acuity, central retinal thickness, or remission duration between the IVBI group and the control group at baseline or after treatment (p>0.05). CONCLUSIONS: Intravitreal bevacizumab showed no positive effect in acute CSC patients compared to the observation group, and there were no adverse effects of treatment. Further investigation will be helpful to understand this therapy in patients with CSC.
