Recent advance in role of C-type lectin-like receptor 2 in acute ischemic stroke

VernacularTitle:C型凝集素样受体2在急性缺血性脑卒中中的研究进展
Author: Ya'nan JIA ¹ ; Fengyun HU ; Wenjun CHEN
Author Information

1. 山西医科大学附属人民医院神经内科，太原　030012
Keywords: Acute ischemic stroke; C-type lectin-like receptor 2; Thrombus inflammation; Biomarker
From: Chinese Journal of Neuromedicine 2021;20(9):948-951
CountryChina
Language:Chinese
Abstract: Acute ischemic stroke (AIS) is one of the main causes of death and disability in adults, which has brought a heavy burden to society and families. The intertwined process of thrombosis and thrombus inflammation plays a key role in the pathogenesis of AIS. The latest studies find that C-type lectin-like receptor 2 (CLEC-2) may play an important role in cerebral ischemia/reperfusion injury in mice by promoting thrombus inflammation, and its level is related to the progression of AIS and prognoses of patients with AIS. The author reviews the physiological and pathological effects of CLEC-2 and its related research progress in AIS, with a view to provide new research evidences for the occurrence and development of AIS and related treatments.