Triple fusion PET/MRI in location of epileptogenic focus in patients with focal cortical dysplasia
10.3760/cma.j.cn115354-20210608-00370
- VernacularTitle:三重融合PET/MRI在局灶性脑皮质发育不良导致的癫痫病灶定位中的初步应用
- Author:
Yi JIN
1
;
Chaoling JIN
;
Yumin ZHENG
;
Tian LIANG
;
Sheng XIE
;
Xiaoxuan LI
;
Dantao PENG
;
Pei RONG
;
Dongyan WU
Author Information
1. 中日友好医院神经内科，北京 100029
- Keywords:
Focal cortical dysplasia;
Positron emission tomography;
MR imaging;
Cross modality image fusion
- From:
Chinese Journal of Neuromedicine
2021;20(9):915-920
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of triple fusion positron emission tomography (PET)/MRI in location of epileptogenic focus in patients with focal cortical dysplasia (FCD).Methods:Three patients with refractory partial epilepsy, admitted to our hospital from December 2016 to June 2017, were chosen in our study. The raw MRI and PET images of these patients were processed using Freesurfer and FSL image processing softwares. After extraction and coregistration, precise PET/MRI fusion images were obtained; and the grey-white matter dividing line was highlighted on this fusion image to form triple-fusion images to observe the hypometabolic area and clarify the location.Results:Triple-fusion images of these 3 patients were acquired. In patient 1, a marked decrease in metabolism was noted in the gyrus region delineated by the gray-white matter boundary in the right cingulate gyrus. In patient 2, the area with slightly increased local signal in the right superior frontal gyrus (MRI FLAIR sequence) was the area with reduced metabolism. In patient 3, an area of local decreased metabolism was noted in the right cingulate gyrus. The preoperative evaluation of all 3 patients showed that the above areas were epileptic foci; the patients were followed up for 2 years after surgical resection, no clinical seizures occurred in all patients, and antiepileptic drugs were gradually stopped. All 3 patients were diagnosed as having FCD by postoperative pathology.Conclusion:Triple fusion PET/MRI is a powerful way to assist FCD diagnosis, especially for those FCD cases which are difficult to be diagnosed by other imaging methods, and has a potential clinical application value in epilepsy patients.
