Recent advance in role of Orai1-STIM1-TRPC1 complete functional complex in Parkinson's disease
10.3760/cma.j.cn115354-20210102-00002
- VernacularTitle:Orai1-STIM1-TRPC1功能复合体在帕金森病中的研究进展
- Author:
Xiaofang LIU
1
;
Zhixiao ZHANG
;
Li WANG
Author Information
1. 山西医科大学第二临床医学院，太原 030000
- Keywords:
Calcium release-activated calcium modulator 1 Orai1;
Stromal interaction molecule 1;
Transient receptor potential channel 1;
Store-operated calcium entry
- From:
Chinese Journal of Neuromedicine
2021;20(8):839-843
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease is the second most common neurodegeneration, and its pathogenesis is related to mitochondrial dysfunction, oxidative stress and calcium homeostasis imbalance. In recent years, the relationship between Parkinson's disease and Ca 2+ has become a research hotspot. Calcium homeostasis disorders can lead to Parkinson's disease in different ways. The level of intracellular calcium ion depends on store-operated calcium entry (SOCE), calcium release-activated calcium modulator1 (Orai1), stromal interaction molecule 1 (STIM1) and transient receptor potential channel 1 (TRPC1) can form a functional complex to regulate it. PD neurotoxins can selectively damage dopaminergic neurons by reducing the function of Orai1-STIM1-TRPC1 complex and damaging SOCE and its downstream signal pathways. And the complex may affect the development of Parkinson's disease by acting on microglia and endoplasmic reticulum stress, and then regulate neuroinflammation and autophagy. Therefore, restoring the expression and function of Orai1-STIM1-TRPC1 function complex and maintaining calcium homeostasis may be the therapeutic targets of Parkinson's disease.
