Recent advance in HMGB1-TLR pathway in epileptogenesis and epilepsy treatment

VernacularTitle:HMGB1-TLR信号通路在癫痫发生及治疗中的研究进展
Author: Shu WANG ¹ ; Yuguang GUAN
Author Information

1. 首都医科大学三博脑科医院神经外科，北京市临床医学研究癫痫病重点实验室，北京脑重大疾病研究院癫痫研究所　100093
Keywords: Epilepsy; High Mobility Group Box 1; Toll-like receptor
From: Chinese Journal of Neuromedicine 2021;20(8):833-838
CountryChina
Language:Chinese
Abstract: Epilepsy is one of the most common neurological diseases, which has serious impact in patients, families, and society. Antiepileptic drugs and surgeries are widely used for epilepsy treatment. However, there are still many patients have drug-resistant epilepsy, and various adverse reactions are reported during treatment. Recently, researches on neuroinflammation process mediated by high mobility group box 1 (HMGB1)-Toll-like receptor (TLR) pathway show that it has great potential in exploring epileptogenesis and epilepsy treatment. In this paper, the recent advance in this signaling pathway in the occurrence and treatment of epilepsy is reviewed and its future development prospect is expected to provide some references for the development of new epilepsy treatment targeting HMGB1-TLR signaling pathway.