Correlation of pericyte-mediated cerebral microcirculation disturbance with central nervous system diseases
10.3760/cma.j.cn115354-20200610-00468
- VernacularTitle:周细胞介导脑微循环障碍在中枢神经系统疾病中的相关性研究
- Author:
Shaorui ZHENG
1
;
Xiangrong CHEN
;
Shousen WANG
Author Information
1. 福建医科大学福总临床医学院神经外科，福州 350025
- Keywords:
Pericyte;
Brain microcirculation;
Neurovascular coupling;
Central nervous system disease
- From:
Chinese Journal of Neuromedicine
2021;20(7):738-742
- CountryChina
- Language:Chinese
-
Abstract:
Pericytes are a kind of microvascular parietal cells, which constitute neurovascular units together with neurons, astrocytes, microglia, vascular endothelial cells and vascular smooth muscle cells to maintain the basic function of the brain. Pericyte dysfunction can lead to cerebral microcirculation dysfunction, which is related to the occurrence and development of a variety of nervous system diseases. This article reviews the characteristics, identification and subtypes of pericytes, their relations with cerebral microcirculation, and their correlation with central nervous system diseases.
