Role of microglia in neuroinflammation after traumatic brain injury and its significance in nerve regeneration
10.3760/cma.j.cn115354-20200717-00573
- VernacularTitle:创伤性脑损伤神经炎症环境中小胶质细胞的作用及其对神经再生修复的意义
- Author:
Yibin JIA
1
;
Guanyi WANG
;
Enming KANG
;
Huijun CHEN
;
Xiaosheng HE
Author Information
1. 空军军医大学西京医院神经外科，西安 710032
- Keywords:
Brain injury;
Neuroinflammation;
Microglia;
Nerve regeneration
- From:
Chinese Journal of Neuromedicine
2021;20(7):733-737
- CountryChina
- Language:Chinese
-
Abstract:
The secondary damage after traumatic brain injury (TBI) involves a variety of pathological processes, and the inflammatory response in the nervous system is an important factor which affects nerve repair and regeneration. As the innate immune cell in the nervous system, microglia (MG) plays an important role in the entire neuroinflammatory environment by regulating the activation state of MG and changing the inflammatory response in the direction of promoting nerve repair and regeneration, which has great potential in treatment of TBI. This article reviews the inflammatory response of the nervous system after TBI and the reactivity of MG, as well as their significance in nerve repair and regeneration.
