Recent advance in N6-methyladenine methylation regulating neurodevelopment and neurological diseases
10.3760/cma.j.cn115354-20200306-00150
- VernacularTitle:m6A甲基化调控神经系统及相关疾病的功能研究进展
- Author:
Zhihao LIU
1
;
Yan TENG
;
Lu YANG
Author Information
1. 电子科技大学医学院基础医学部，成都 610054
- Keywords:
N6-methyladenine;
Epigenetics;
Methyltransferase;
Demethylase;
Neurological disease
- From:
Chinese Journal of Neuromedicine
2021;20(7):727-732
- CountryChina
- Language:Chinese
-
Abstract:
Among the abundant known modifications that occur within messenger RNA (mRNA), N6-methyladenine (m6A) is the most common post-transcriptional modification in eukaryotes, accounting for almost 80% of all RNA methylation modification. At molecule level, m6A, a reversible modification, participates in regulation of the shearing, nucleation, translation, and degradation of mRNA. Existing studies have also revealed that m6A modification is involved in multiple physiological and pathological processes such as DNA damage repair, stem cell self-renew and differentiation, growth and development, learning and memory, and immune regulation; this kind of modification has also become an important research direction in the field of neuroscience recently. This article mainly summarizes recent processes in the molecular mechanisms of m6A methylation and its relevance to the neurodevelopment and neurological diseases, with aim to provide a comprehensive understanding of m6A regulation in this research area.
