Reperfusion therapy in wake-up stroke patients under guidance of "tissue-window": an efficacy and safety study
10.3760/cma.j.cn115354-20201022-00830
- VernacularTitle:多模式CT"组织窗"指导下醒后脑卒中再灌注治疗的有效性和安全性研究
- Author:
Xianxian ZHANG
1
;
Xiuying CAI
;
Hui WANG
;
Yizhi LIU
;
Feirong YAO
;
Haicun SHI
;
Qi FANG
Author Information
1. 盐城市第三人民医院、南通大学第六附属医院神经内科 224001
- Keywords:
Wake-up stroke;
Computed tomography perfusion;
Reperfusion therapy;
Tissue-window
- From:
Chinese Journal of Neuromedicine
2021;20(7):674-681
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of reperfusion therapy in patients with wake-up stroke (WUS) under the guidance of "tissue-window" by comparing with patients with non-WUS who received reperfusion therapy within "time-window".Methods:Two hundred and thirty-five acute ischemic stroke patients admitted to our hospital from January 2018 to December 2019 were enrolled in our study. Patients with non-WUS received reperfusion therapy within "time-window"; patients with WUS accepted multimodal CT examination at Emergency right after admission, Mistar software was used to reconstruct CT perfusion imaging (CTP) images, and reperfusion therapy was given to these patients after the judgement of "tissue-window". The differences of clinical data, prognoses, and safety indexes were compared between patients with WUS and non-WUS.Results:In these 235 patients, 45 patients were with WUS and 190 were with non-WUS. As compared with patients with non-WUS, those with WUS had significantly lower percentages of patients with hypertension history and patients accepted intravenous thrombolysis ( P<0.05). In 153 patients accepted intravenous thrombolysis, 23 patients were with WUS and 130 were with non-WUS; the time from admission to intravenous thrombolysis in WUS patients was significantly longer than that in non-WUS patients ( P<0.05); the clinical data, prognoses, and safety indexes showed no significant differences between these patients with WUS and non-WUS ( P>0.05). In 82 patients accepted bridging thrombectomy and direct thrombectomy, 22 patients were with WUS and 60 were with non-WUS; the clinical data, prognoses, and safety indexes showed no significant differences between these patients with WUS and non-WUS ( P>0.05). Conclusion:By comparing with patients with non-WUS who received reperfusion therapy within "time-window", reperfusion therapy is effective and safe for WUS patients under the guidance of multimodal CT "tissue-window".
