Castleman's Disease Presenting with Uveal Effusion Syndrome.
10.3341/kjo.2010.24.3.182
- Author:
Sang Hoon PARK
1
;
Su Jeong SONG
Author Information
1. Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. eye-su@hanmail.net
- Publication Type:Case Report
- Keywords:
Choroidal detachment;
Giant lymph node hyperplasia;
Uveal effusion
- MeSH:
Aged;
Choroid Diseases/etiology;
Drug Therapy, Combination;
Exudates and Transudates/*metabolism;
Fluorescein Angiography;
Fundus Oculi;
Giant Lymph Node Hyperplasia/*complications/drug therapy;
Humans;
Hypergammaglobulinemia/complications;
Magnetic Resonance Imaging;
Male;
Syndrome;
Tomography, Optical Coherence;
Treatment Outcome;
Uveal Diseases/diagnosis/*etiology/*metabolism
- From:Korean Journal of Ophthalmology
2010;24(3):182-185
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a rare case of multicentric Castleman's disease that presented with ophthalmic involvement, along with a review of the literature. A 63-year-old male presented with decreased visual acuity in both eyes. Both eyes had serous elevations of the retinas with shifting subretinal fluid and annular choroidal detachment. No retinal breaks were found. Laboratory tests revealed pancytopenia, hypergammaglobulinemia, and an increased erythrocyte sedimentation rate. Chest and abdominal computed tomographies showed multiple lymphadenopathies in the mediastinum, abdomen, and in both inguinal areas. Histological examination of the inguinal lymph node biopsy was consistent with Castleman's disease. After combination chemotherapy, the serous elevations of both retinas and the annular choroidal detachments of both eyes disappeared. Ophthalmic involvement in Castleman's disease is very rare, and to the authors' knowledge, this is the first report of ophthalmic involvement of Castlemans's disease in Korea.
