Recent advance in relation of aquaporin 4 with Alzheimer's disease

VernacularTitle:水通道蛋白4与阿尔茨海默病的关系研究进展
Author: Shuang ZHANG ¹ ; Xiaoxue HUANG ; Lulu YAN ; Yao TANG ; Jun WU
Author Information

1. 郑州大学第一附属医院神经内科，郑州　450052
Keywords: Alzheimer's disease; Aquaporin 4; Neurodegenerative disease
From: Chinese Journal of Neuromedicine 2021;20(4):406-411
CountryChina
Language:Chinese
Abstract: Alzheimer's disease (AD) is a neurodegenerative disease mainly manifested by progressive cognitive impairment, which is seriously harmful to human health and causes a heavy burden to society and family. Aquaporin 4 (AQP4) is an important type of aquaporins (AQPs) in mammalian brain, and more and more studies have found that it plays an important role in the occurrence and development of AD. In this paper, the structure, distribution and function of AQP4 are summarized, and various ways of its participation in the pathogenesis of AD are systematically described to provide reference for the treatment of AD.