Recent advance in mechanism of reactive astrocytes in optic nerve injury
10.3760/cma.j.cn115354-20200227-00126
- VernacularTitle:星形胶质细胞活化在视神经损伤中的研究进展
- Author:
Mingxu ZHANG
1
;
Jiawei YANG
;
Xiulan ZHAO
;
Ying ZHAO
;
Siquan ZHU
Author Information
1. 成都中医药大学眼科学院，成都 610000
- Keywords:
Astrocyte reactivity;
Ganglion cell;
Central nerve system;
Optic nerve injury;
Degenerative neuropathy
- From:
Chinese Journal of Neuromedicine
2021;20(3):313-318
- CountryChina
- Language:Chinese
-
Abstract:
The optic nerve is the only pathway that transduct visual signals into visual centers, and is consisted of retinal ganglion cells and glial cells. Astrocytes, the most abundant neuroglia in center nerve system (CNS), are considered as structural supporter and carrier of metabolic components of neurons. In recent years, astrocytes have become treasure of neurological study due to their dual effects after nerve injury. The neurotoxic reactive astrocytes are termed as A1-type, and the neuroprotective ones are termed as A2-type. For the purpose of reducing neuron loss after optic nerve injury, it is critical to find out proper management methods of astrocyte reactivity. In this paper, we will concentrate on the inducers, mechanisms and influences of astrocyte reactivity in optic nerve and CNS, and then, summarize present possible interference ways to a neuroprotective outcome.
