Recent advance in epigenetic regulation of oligodendrocyte lineages
10.3760/cma.j.cn115354-20200222-00103
- VernacularTitle:少突胶质细胞表观遗传学调控机制的研究进展
- Author:
Tianyang QIAN
1
;
Han QIU
;
Laishuan WANG
Author Information
1. 国家卫生和健康委员会新生儿疾病重点实验室、复旦大学附属儿科医院新生儿科，上海 201102
- Keywords:
Oligodendrocyte;
Oligodendrocyte precursor cell;
Myelin formation;
Epigenetics
- From:
Chinese Journal of Neuromedicine
2021;20(3):302-307
- CountryChina
- Language:Chinese
-
Abstract:
Developmental oligodendrocyte lineages are regulated by internal and external factors during the processes of stereotyping, specialization, proliferation, migration, differentiation, maturation, myelination and myelin remodeling in demyelinating diseases. In recent years, the mechanisms of epigenetics in these processes have been studied extensively, including DNA methylation, histone modification, non-coding RNA and chromatin remodeling; these mechanisms provide potential new targets for treatment of myelin formation disorders or myelin-destructive diseases such as multiple sclerosis, periventricular leukomalacia and encephalomyelitis in preterm infants. This article reviews recent research advance in epigenetics in the development and regeneration of oligodendrocyte lineages.
