Clinical characteristics of paroxysmal sympathetic hyperactivity in children with acute brain injury
10.3760/cma.j.cn115354-20200915-00735
- VernacularTitle:急性脑损伤伴PSH患儿的临床特征分析
- Author:
Shuo FENG
1
;
Jinxiao CHEN
;
Ping ZHENG
;
Shuo LIU
;
Jing SUN
;
Qian CHEN
Author Information
1. 首都儿科研究所附属儿童医院神经内科，北京 100020
- Keywords:
Paroxysmal sympathetic hyperactivity;
Acute brain injury;
Children;
Clinical feature
- From:
Chinese Journal of Neuromedicine
2021;20(2):182-187
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical characteristics of paroxysmal sympathetic hyperactivity (PSH) in children with acute brain injury.Methods:The clinical characteristics, hospitalization data, hospitalization cost, and prognoses of 40 children with acute brain injury admitted to our hospital from June 2018 to June 2020 were retrospectively summarized. In addition, the differences of above data between children with PSH and children without PSH were comparatively analyzed.Results:Nine children were with PSH, with an incidence of 22.5%; five were with anti- N-methyl- D-aspartate receptor (NMDAR) encephalitis, two were with acute necrotizing encephalopathy, and two were with severe viral encephalitis. Thirty-one children were without PSH; five were with metabolic encephalopathy, 19 were with viral encephalitis, three were with anti-NMDAR encephalitis, one was with acute cerebral infarction, one was with primary central nervous system lymphoma, one was with acute necrotizing encephalopathy, and one was with severe closed head injury. The patients with PSH had significantly higher proportion of patients with anti-NMDAR encephalitis, significantly higher hospitalization cost, statistically longer duration of disorder of consciousness and hospital stays, and significantly lower Glasgow coma scale (GCS) scores at discharge than the patients without PSH ( P<0.05). Conclusion:PSH is common in children with acute brain injury; PSH can lead to a long period of disorders of consciousness, long hospital stays, high hospitalization cost, and poor prognosis, which causes an increase in family and social burdens.
