Changes of serum heme oxygenase 1 level and its correlation with clinical characteristics in patients with acute cerebral infarction before and after successful recanalization
10.3760/cma.j.cn115354-20200519-00378
- VernacularTitle:急性脑梗死患者血管成功再通前后血清HO-1水平变化及其与患者临床特征的关系
- Author:
Bo YANG
1
;
Jianhong WANG
;
Nengwei YU
Author Information
1. 西南医科大学临床医学院，泸州 646000
- Keywords:
Heme oxygenase 1;
Acute cerebral infarction;
Endovascular treatment;
Cerebral ischemia-reperfusion injury
- From:
Chinese Journal of Neuromedicine
2020;19(12):1247-1252
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes of serum heme oxygenase 1 (HO-1) level and its correlation with clinical characteristics in patients with acute cerebral infarction (ACI) before and after successful recanalization.Methods:Twenty-nine ACI patients accepted mechanical thrombectomy and enjoyed successful vascular recanalization (Thrombolysis in Cerebral Infarction (mTICI) grading≥2B) in our hospital from November 2018 to September 2019 were enrolled as observation group; 22 patients suspected for carotid artery stenosis or cerebral aneurysm underwent DSA (DSA ruled out the intracranial and carotid artery lesions) were chosen as control group. The level of HO-1 was measured by ELISA before and one, three and 7 d after surgery in the observation group, and before and after DSA in the control group. Besides, the correlation of HO-1 expression level with clinical characteristics of patients in the observation group was analyzed.Results:(1) As compared with the control group before DSA, the serum HO-1 level in the observation group before surgery was significantly higher ( P<0.05); and the serum HO-1 level in the observation group 7 d after surgery was significantly higher than that before and one d after surgery ( P<0.05). (2) Preoperative serum HO-1 level in patients with preoperative scores of diffusion weighted imaging (DWI)-Alberta stroke program early CT (ASPECT)≤7 was significantly higher than that in patients with DWI-ASPECT scores>7 from the observation group ( P<0.05). Preoperative serum HO-1 level in patients with baseline National Institutes of Health stroke scale (NIHSS) score≤12 was significantly lower than that in patients with NIHSS scores>12 from the observation group ( P<0.05). The preoperative serum HO-1 level was negatively correlated with DWI-ASPECTS scores ( r=-0.560, P=0.002) and positively correlated with baseline NIHSS scores ( r=0.685, P=0.001). (3) There was no difference in serum HO-1 level between mTICI grading 2B patients and mTICI grading 3 patients from the observation group ( P>0.05); but for patients with mTICI grading 3, the serum HO-1 level 7 d after surgery was significantly higher than that one d after surgery ( P<0.05). (4) The serum HO-1 level in patients with hemorrhagic transformation 3 and 7 d after surgery was significantly higher than that in patients without hemorrhagic transformation from the observation group ( P<0.05); the serum HO-1 level in patients with hemorrhagic transformation 7 d after surgery was significantly higher than that one d after surgery ( P<0.05). Conclusion:The serum HO-1 level is increased in patients with ACI, and it will further increase after successful recanalization; the serum HO-1 level is related with early infarction degree and neurological deficit degree before surgery, recanalization level and hemorrhagic transformation after surgery.
