Recent advance in mechanism of cognitive impairment induced by brain ionization radiation
10.3760/cma.j.cn115354-20191231-00785
- VernacularTitle:脑电离辐射导致认知功能障碍的机制研究进展
- Author:
Yanlin MO
1
;
Ling LI
Author Information
1. 广西医科大学附属肿瘤医院放疗科，南宁 530021
- Keywords:
Brain tumor;
Ionization radiation;
Cognitive impairment;
Mechanism
- From:
Chinese Journal of Neuromedicine
2020;19(12):1288-1291
- CountryChina
- Language:Chinese
-
Abstract:
Nerve toxicity, such as cognitive dysfunction, often appears in patients with brain tumors after radiotherapy. Cognitive dysfunction after radiotherapy can even appear in patients with extra-cranial tumors such as head and neck cancers. These declines in cognition can seriously affect the patient's quality of life. Therefore, it is very important to find a clear mechanism of brain ionization radiation induced cognitive impairment. At present, the exact mechanism of brain ionization radiation induced cognitive impairment is unclear, and it may be mainly associated with the decline of hippocampal neurogenesis, changes of microenvironment, inflammation, oxidative stress, vascular injury and blood-brain barrier damage, dendritic morphology and N-methyl- D aspartate changes. This review summarizes the recent advance in main mechanism of brain ionization radiation induced cognitive impairment.
