Recent advance in roles of brain-derived neurotrophic factor-tyrosine receptor kinase B signaling pathway genes and their encoded proteins in epilepsy
10.3760/cma.j.cn115354-20191019-00606
- VernacularTitle:BDNF-TrkB信号通路基因及其编码蛋白在癫痫中的作用研究进展
- Author:
Shitao WANG
1
;
Jin LONG
;
Liang ZHOU
;
Yanbing HAN
Author Information
1. 昆明医科大学第一附属医院神经内科，昆明 650032
- Keywords:
Epilepsy;
Brain-derived neurotrophic factor;
Tyrosine receptor kinase B
- From:
Chinese Journal of Neuromedicine
2020;19(12):1269-1272
- CountryChina
- Language:Chinese
-
Abstract:
Brain-derived neurotrophic factor (BDNF) and tyrosine receptor kinase B (TrkB) signaling pathway may play important roles in a variety of neurological diseases, particularly in the development and treatment of epilepsy. The BDNF gene and NTRK2 gene are genes encoding BDNF and TrkB proteins in this pathway. The variations in these two genes may affect the occurrence and treatment of epilepsy through leading to abnormal functions and expressions of the encoded proteins, which may affect the degrees of activation of BDNF-TrkB signaling pathway. This article summarizes the pathophysiological processes of epilepsy in which BDNF-TrkB signaling pathway genes and their encoded proteins may be involved.
