Mechanism and prospect of disease-associated microglia in neurodegeneration after traumatic brain injury
10.3760/cma.j.cn115354-20200310-00167
- VernacularTitle:疾病相关性小胶质细胞在创伤性颅脑损伤后神经变性中的作用机制及展望
- Author:
Yangbiao WU
1
;
Xianzhe ZHOU
;
Shipeng LI
;
Wenqi LYU
;
Jieran YAO
;
Xiangrong CHEN
Author Information
1. 福建医科大学第二临床医学院，泉州 362000
- Keywords:
Microglia;
Traumatic brain injury;
Neurodegeneration;
Neurodegeneration associated molecular pattern
- From:
Chinese Journal of Neuromedicine
2020;19(12):1283-1287
- CountryChina
- Language:Chinese
-
Abstract:
The pathological processes of neurodegeneration and neurodegenerative changes after traumatic brain injury (TBI) are closely related to microglia. The pathophysiological functions of microglia are closely correlated to their different cell subtypes. Disease-related microglia (DAM) are a special subtype of microglia, which recently discover on the lesions of degenerative diseases of the central nervous system. DAM are identified as important cells that induce neurodegeneration. The in-depth discussion of DAM role in pathological mechanism of neurodegeneration after TBI provides new clues for understanding and treating neurodegeneration after TBI; therefore, this article focuses on the above content and summarizes the research progress of DAM and neurodegeneration after TBI.
