Expression of ATP binding cassette subfamily C member 8 and its clinical significance in gliomas
10.3760/cma.j.cn115354-20200714-00563
- VernacularTitle:ABCC8在胶质瘤中的表达及其临床意义
- Author:
Kaijia ZHOU
1
;
Yanwei LIU
;
Zheng ZHAO
;
Ming ZHANG
;
Bowei LIU
Author Information
1. 福建省肿瘤医院 福建医科大学附属肿瘤医院神经肿瘤外科，福州 350014
- Keywords:
Glioma;
ATP binding cassette subfamily C member 8;
Prognosis evaluation
- From:
Chinese Journal of Neuromedicine
2020;19(12):1260-1266
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the expression of ATP binding cassette subfamily C member 8 (ABCC8) in different types of gliomas and its relation with overall survival of glioma patients.Methods:The ABCC8 mRNA data and clinical data (gender, age, histopathology, WHO grading, isocitrate dehydrogenase [ IDH] mutation status, 1p/19q deletion status and molecular types), and overall survival of 516 glioma patients from the Cancer Genome Atlas were collected, and the differences of ABCC8 mRNA expression in different types of glioma patients were compared. The differences of overall survival were compared between high (≥54.50) and low (<54.50) ABCC8 mRNA expression patients in different types of glioma patients. Results:(1) ABCC8 mRNA expression in primary glioma patients was significantly higher than that in recurrent glioma patients ( P<0.05). ABCC8 mRNA expression was the highest in oligodendroglioma patients, followed by astrocytoma patients; and glioblastoma patients had the lowest ABCC8 mRNA expression; the differences among glioma patients from subgroups of different histopathological types were statistically significant ( P<0.05). ABCC8 mRNA expression was the highest in patients with grade II glioma, followed by those with grade III ( P<0.05); and patients with grade IV had the lowest ABCC8 mRNA expression ( P<0.05); the differences among patients from subgroups of different WHO grading were statistically significant ( P<0.05). ABCC8 mRNA expression in glioma patients with IDH mutant was significantly higher than that in glioma patients with IDH wild-type ( P<0.05); and ABCC8 mRNA expression in patients with 1P/19Q deletion glioma was significantly higher than that in patients with 1P/19Q deletion ( P<0.05). ABCC8 mRNA expression in low-grade glioma patients and glioblastoma multiforme patients with IDH mutation was significantly higher than that in patients with IDH wild-type ( P<0.05). (2) In all patients with glioma, primary and recurrent glioma, oligodendroglioma, neuroastrocytoma, WHO low-grading (grade II) and WHO high-grading (grade III or IV) glioma, IDH mutation and IDH wild-type gliomas, and 1p/19q deletion and no deletion gliomas, patients with high ABCC8 mRNA expression had significantly higher overall survival time that those with low ABCC8 mRNA expression ( P<0.05). (3) Multivariate Cox analysis showed that ABCC8 mRNA expression was an independent factor for overall survival of patients with gliomas ( HR=0.747, P=0.025, 95%CI:0.579-0.963). Conclusion:The ABCC8 mRNA expression in glioma patients is related to the malignant degrees of gliomas, which can be used as an indicator to predict the prognoses of gliomas.
