Recent advance in early diagnosis biomarkers of Creutzfeldt-Jakob disease
10.3760/cma.j.cn115354-20200704-00534
- VernacularTitle:克雅病早期诊断生物标志物的研究进展
- Author:
Jing YANG
1
;
Jie PANG
;
Lanjun LI
;
Yanpeng YUAN
;
Yuming XU
Author Information
1. 郑州大学第一附属医院神经内科，郑州 450052
- Keywords:
Creutzfeldt-Jakob disease;
Early diagnosis;
Biomarker;
Protease-resistant prion protein;
Protein misfolding cyclic amplification;
Real-time quaking-induced
- From:
Chinese Journal of Neuromedicine
2020;19(12):1292-1296
- CountryChina
- Language:Chinese
-
Abstract:
Creutzfeldt-Jakob disease is a type of fatal central nervous system degeneration caused by infectious pathogenic prion protein. The early clinical manifestations of the disease are diverse and lack of specificity, so it is difficult to distinguish it from other neurological diseases. Researchers have made long-term exploration and clinical applications in imaging, electroencephalography, and detection of special proteins in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. In recent years, the development of new methods for the detection of pathogenic prion protein has provided great help for the early diagnosis of the disease, and it has great clinical application prospects. This article reviews the current research on the epidemiology, etiology and pathological mechanism and early diagnosis biomarkers of Creutzfeldt-Jakob disease, in order to help clinical colleagues to further enhance the understanding of Creutzfeldt-Jakob disease.
