Recent advance in relations of intracerebral chronic inflammation and gut-brain axis with Alzheimer's disease
10.3760/cma.j.cn115354-20200801-00619
- VernacularTitle:脑内慢性炎症及肠-脑轴与阿尔茨海默病的关系研究进展
- Author:
Shunfen ZHANG
1
;
Wuhua XU
Author Information
1. 贵州医科大学临床医学院，贵阳 550004
- Keywords:
Alzheimer's disease;
Gut-brain axis;
Intestinal flora;
Glial cell;
Chronic inflammation
- From:
Chinese Journal of Neuromedicine
2020;19(11):1176-1180
- CountryChina
- Language:Chinese
-
Abstract:
More and more evidences suggest that the gut-brain axis is comprehensively involved in the entire pathological courses of Alzheimer's disease (AD), and is a new source of its β-amyloid protein (Aβ) and tau pathologies and chronic inflammations in the brain. In this paper, the potential targets and application prospects in the prevention and treatment of AD are discussed from the aspects of gastrointestinal tract, intracerebral inflammation and intestinal flora.
