Correlation between changes of amplitude of low-frequency fluctuation and cognitive impairment in patients with mild hepatic encephalopathy
10.3760/cma.j.cn115354-20200512-00361
- VernacularTitle:轻微型肝性脑病患者认知功能障碍与脑区低频振幅改变的相关性研究
- Author:
Jiang JI
1
;
Chaoyun ZHAO
;
Yiyang LIU
;
Danqing ZHANG
;
Ya WANG
;
Xiangchun DING
;
Xiaodong WANG
Author Information
1. 宁夏医科大学总医院放射科，银川 750000
- Keywords:
Minimal hepatic encephalopathy;
Amplitude of low-frequency fluctuation;
Cognitive impairment;
Resting-state blood oxygen level-dependent functional magne
- From:
Chinese Journal of Neuromedicine
2020;19(11):1109-1115
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation of cognitive impairment with abnormal brain regions having low-frequency fluctuation (ALFF) by resting-state blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) in patients with mild hepatic encephalopathy (MHE).Methods:Fifty-nine patients (28 patients with chronic cirrhosis and 31 patients with MHE, according to results of digital symbol test [DST] scores/digital connection test A [NCT-A] scores) admitted to our hospital from March 2018 to January 2020 were enrolled; 33 healthy control subjects matched in gender, age and years of education were chosen as controls. Resting-state BOLD-fMRI was performed in all subjects, and the original images were processed to obtain ALFF brain map. Statistical methods were used to obtain the brain regions with different ALFF values in the three groups, and the brain regions enjoying correlations between ALFF values and venous blood ammonia content/DST scores/NCFA scores in patients from the MHE group.Results:As compared with the control group, patients in the MHE group exhibited significantly lower ALFF values in the right central posterior gyrus, bilateral cuneiform lobe, left lateral occipital gyrus, left occipital gyrus, and left pars opercularis, and significantly increased ALFF values in the right thalamus, left parahippocampal gyrus and surrounding ventricle (bilateral caudate nucleus head)( P<0.05). Bivariate correlation analysis suggested that ALFF values were negatively correlated with blood ammonia in the left pars opercularis, left margin superior gyrus, bilateral precuneus, left superior temporal gyrus, right middle frontal gyrus and surrounding area, and right insula ( P<0.05); ALFF values were positively correlated with DST scores in left medial cingulate gyrus and right cerebellar hemisphere; ALFF values in the left frontal lobe and left posterior cerebellar lobe were positively correlated with NCT-A scores, and ALFF values in the left parahippocampal gyrus were negatively correlated with NCT-A scores ( P<0.05). Conclusion:The ALFF differences in multiple brain regions of patients with MHE may be related to cognitive impairment.
