Correlation between enhancement rate of aneurysm wall detected by high-resolution magnetic resonance vessel wall imaging and risk of intracranial aneurysm rupture
10.3760/cma.j.cn115354-20200609-00463
- VernacularTitle:高分辨血管壁成像显示的瘤壁强化程度与颅内动脉瘤破裂风险的关联研究
- Author:
Sijing CHEN
1
;
Jianxun SONG
;
Nianxia FU
;
Guohui LIN
;
Dihao XU
;
Liling ZHONG
Author Information
1. 广东医科大学第一临床医学院，湛江 524000
- Keywords:
Intracranial aneurysm;
PHASES scale;
High-resolution magnetic resonance vessel wall imaging;
Rupture risk
- From:
Chinese Journal of Neuromedicine
2020;19(11):1116-1121
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of enhancement rate of aneurysm wall by high-resolution magnetic resonance vessel wall imaging (HR-VWI) in assessing the risk of intracranial aneurysm rupture.Methods:Seventy patients with 80 intracranial aneurysms, admitted to our hospital from January 2016 to December 2019, were chosen in our study; morphological parameters (shape, neck width, height, diameter) of the intracranial aneurysms, and signal intensity and enhancement rate of aneurysm wall were collected from HR-VWI. These patients were divided into a high-risk rupture group (PHASES scores>3) and a low-risk rupture group (PHASES scores≤3) according to PHASES scores. Univariate analysis was used to compare the differences of clinical data (age, gender, blood pressure, blood lipids, and smoking history) and aneurysm imaging data between the two groups of patients. Multivariable Logistic regression was used to determine the independent influencing factors for aneurysm rupture, and receiver-operating characteristic (ROC) curve of enhancement rate of aneurysm wall in predicting aneurysm rupture was drew to determine the best diagnostic value.Results:Univariate analysis showed that the percentages of patients with hypertension, multiple aneurysms and irregular aneurysm morphology, aneurysm height, aneurysm diameter and aneurysm wall enhancement rate were significantly different between the high-risk rupture group and low-risk rupture group ( P<0.05). Multivariate Logistic regression analysis showed that aneurysm diameter ( OR=1.647, 95%CI: 1.177-2.306, P=0.004) and aneurysm wall enhancement rate ( OR=5.317, 95%CI: 1.527-18.512, P=0.009) were independent influencing factors for rupture of intracranial aneurysms. The area of ROC curve was 0.735, the optimal cut-off value was 0.583; the sensitivity of predicting rupture of intracranial aneurysms was 72.7% and the specificity was 70.2%. Conclusion:The aneurysm wall enhancement rate is significantly correlated with risk of aneurysm rupture; when the PHASES scores>3 and aneurysm wall enhancement rate>58.3%, clinical intervention should be vigilant.
