Micro RNA is involved in progression of secondary pathological process of traumatic brain injury
10.3760/cma.j.cn115354-20200226-00122
- VernacularTitle:miRNA介导创伤性颅脑损伤继发性损伤病理机制的研究进展
- Author:
Kefeng ZHAI
1
;
Hong DUAN
;
Jiajie WANG
;
Jia WU
;
Junjun WANG
Author Information
1. 宿州学院生物与食品工程学院，宿州 234000
- Keywords:
Traumatic brain injury;
Micro RNA;
Cell apoptosis;
Inflammatory response;
Blood brain barrier
- From:
Chinese Journal of Neuromedicine
2020;19(10):1052-1056
- CountryChina
- Language:Chinese
-
Abstract:
Traumatic brain injury (TBI) is a kind of disease in which brain tissue injury and brain dysfunction are caused by external trauma. At present, the pathological mechanism of TBI is not fully clear, and there is no good clinical treatment plan. TBI can be preliminarily divided into primary injury and secondary injury according to the occurrence time. In recent years, a large number of researchers have begun to look for effective biological signaling molecules such as micro RNA (miRNA) to discover and intervene in secondary injury with strong response after TBI as early as possible. MiRNA, as a small non-coding RNA, can play a key role in the pathological process of central nervous system diseases, which is considered as an effective regulator of nerve function under pathophysiological conditions. In this paper, the effects of miRNA on the occurrence, development and recovery of TBI are summarized through the three major mechanisms of nerve cell apoptosis, inflammatory cytokine expression and blood-brain barrier repair, which lays the foundation for researching function of miRNA in TBI.
