Recent advance in regulatory mechanisms of microglial phagocytosis
10.3760/cma.j.cn115354-20200511-00357
- VernacularTitle:小胶质细胞吞噬功能调节机制的研究进展
- Author:
Min SHUI
1
;
Dan WU
;
Anshi WU
Author Information
1. 首都医科大学附属北京朝阳医院麻醉科 100020
- Keywords:
Microglia;
Phagocytosis;
Activated phenotype;
"Eat me" signal;
"Don't eat me" signal
- From:
Chinese Journal of Neuromedicine
2020;19(10):1057-1060
- CountryChina
- Language:Chinese
-
Abstract:
Microglias are resident macrophages in the central nervous system. It is critical for microglias to accurately recognize the apoptotic cells and debris, avoiding engulfment of the adjacent normal neurons. The disturbance of microglial phagocytosis may lead to various neurodegenerative and neuropsychiatric diseases. Polarization to different phenotype of microglias can alter phagocytic activity. Microglia expresses receptors recognizing the "Eat me" and "Don’t eat me" signals to facilitate or suppress the phagocytosis. This article reviews the current knowledge on regulatory mechanisms of microglial phagocytosis, providing new directions for the study of related diseases.
