Role of neurovascular unit dysfunction in traumatic brain injury-induced neurodegeneration
10.3760/cma.j.cn115354-20200310-00168
- VernacularTitle:神经血管单元功能障碍在创伤性颅脑损伤后神经变性中的作用机制
- Author:
Wenqi LYU
1
;
Shipeng LI
;
Xianzhe ZHOU
;
Yangbiao WU
;
Jieran YAO
;
Xiangrong CHEN
Author Information
1. 福建医科大学第二临床医学院神经外科，泉州 362000
- Keywords:
Brain injury;
Neurovascular unit;
Blood-brain barrier;
Microvascular dysfunction;
Neurodegeneration
- From:
Chinese Journal of Neuromedicine
2020;19(8):844-848
- CountryChina
- Language:Chinese
-
Abstract:
The pathological process continues to evolve for a long time after acute phase of traumatic brain injury (TBI), often coupling with neurodegeneration and neurodegenerative complications. Microvascular dysfunction and blood-brain barrier (BBB) dysfunction caused by neurovascular unit (NVU) dysfunction are closely related to the pathological process of many neurodegenerative diseases. The study on the pathological mechanism of neurovascular unit dysfunction is a promising research field of TBI-related neurodegeneration, and also provides a new idea for the treatment of neurodegeneration after TBI. Therefore, this article mainly reviews these.
