Association between DNA methylation in the CpG island of dopamine D2 receptor gene promoter region and persistent postural-perceptual dizziness
10.3760/cma.j.cn115354-20191209-00733
- VernacularTitle:多巴胺受体D2基因启动子区CpG岛DNA甲基化与持续性姿势-知觉性头晕的关系分析
- Author:
Zhihui YAN
1
;
Liping CUI
;
Tianxia YU
;
Min KONG
;
Quntao YU
;
Hui LIANG
;
Chunfu CHEN
Author Information
1. 烟台市烟台山医院神经内科 264008
- Keywords:
Persistent postural-perceptual dizziness;
Dopamine D2 receptor gene;
DNA methylation;
CpG island
- From:
Chinese Journal of Neuromedicine
2020;19(7):715-718
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relation between DNA methylation in the CpG island of dopamine D2 receptor ( DRD2) gene promoter region and persistent postural-perceptual dizziness (PPPD), and explore the molecular mechanism of PPPD. Methods:The disease group consisted of 43 patients diagnosed as having PPPD in our hospital from January 2017 to June 2017, and blood samples were taken at admission. The control group included 45 with acute vestibular peripheral vertigo whose dizziness symptoms did not recrudesce after follow-up for more than 3 months and PPPD diagnosis was excluded in our hospital at the same period; these patients did not take selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs); blood samples in the patients were collected during follow-up. DNA methylation in the CpG island of DRD2 promoter region was detected by disulfite sequencing and the differences between the two groups were compared. Results:The positive rate of DNA methylation in the CpG island of DRD2 promoter region in the disease group was 58.1%, which was significantly higher than that in the control group (15.6%, P<0.05); and the methylation rate of CpG island loci in the disease group (0.15±0.18) was significantly higher than that in the control group (0.04±0.10, P<0.05). Conclusion:The DNA methylation in the CpG island of DRD2 promoter region is associated with onset of PPPD.
