Recent advance in effect of dexmedetomidine on postoperative delirium
10.3760/cma.j.cn115354-20200508-00346
- VernacularTitle:右美托咪定对术后谵妄影响的研究进展
- Author:
Wenhong TANG
1
;
Xiancheng CUI
;
Xiaojun DENG
;
Changfeng CHAI
;
Chengjie GAO
Author Information
1. 解放军第九六〇医院麻醉科，济南 250031
- Keywords:
Dexmedetomidine;
Postoperative delirium;
Inflammatory response;
Sleep disorder
- From:
Chinese Journal of Neuromedicine
2020;19(7):746-749
- CountryChina
- Language:Chinese
-
Abstract:
Postoperative delirium (POD) is one of the common complications of central nervous system after operation. Severe POD can even develop into dementia, which seriously reduces the quality of life. Neuroinflammation and sleep disorder play important roles in the pathogenesis of POD. Dexmedetomidine (DEX) is a commonly used anesthetic in clinic, which is often used in the sedation of ICU patients and clinical anesthesia. DEX can reduce perioperative inflammatory response, improve patient's sleep, and reduce the incidence of POD. In this paper, the effects of DEX on neuroinflammation and sleep are discussed in order to provide evidence for clinical prevention and treatment of POD.
