Recent advance in aluminum induced programmed death of neural cells
10.3760/cma.j.cn115354-20190919-00546
- VernacularTitle:铝诱导神经细胞程序性死亡的研究进展
- Author:
Jiaxi LIU
1
;
Lifeng ZHANG
Author Information
1. 沈阳医学院公共卫生学院，沈阳 110034
- Keywords:
Aluminum;
Neuronal cell;
Programmed cell death
- From:
Chinese Journal of Neuromedicine
2020;19(6):627-631
- CountryChina
- Language:Chinese
-
Abstract:
Aluminium causes nerve cell death, neurotoxicity and eventually learning and cognitive impairment. In multicellular organisms, programmed cell death (PCD), as a basic biological phenomenon of cells, plays an important role in removing unnecessary or abnormal cells. Abnormal regulation of this process is closely related to neurodegenerative diseases. In this paper, the effects of aluminum on PCD, especially neuronal apoptosis, autophagy and programmed necrosis, are summarized to provide some clues for the pathogenesis of neurodegenerative diseases.
