Recent advance in small nerve fiber impairment in Guillain-Barre syndrome
10.3760/cma.j.cn115354-20190723-00423
- VernacularTitle:吉兰-巴雷综合征小纤维损伤的研究进展
- Author:
Mei MAO
1
;
Yan ZHENG
;
Yuanrong YAO
Author Information
1. 贵州省人民医院神经内科，贵阳 550002
- Keywords:
Guillain-Barre syndrome;
Small fiber neuropathy;
Clinical presentation;
Early diagnosis;
Treatment
- From:
Chinese Journal of Neuromedicine
2020;19(6):623-626
- CountryChina
- Language:Chinese
-
Abstract:
Small nerve fibers refer to peripheral afferent small diameter, thinly myelinated Aδ-fibers and unmyelinated C-fibers. Small nerve fiber impairment caused by various mechanisms calls small fiber neuropathy (SFN). Small nerve fiber impairment caused by immune injury in Guillain-Barre Syndrome (GBS) is a common cause of SFN, which is currently reported as a variant of GBS; the main manifestations of small nerve fiber impairment of GBS are sense disturbance to pain and temperature and autonomic nerve dysfunction. Small nerve fiber impairment of GBS is widely correlated with the prognosis and mortality of GBS. At present, researches on small nerve fiber impairment of GBS are mainly based on case reports, and its diagnosis mainly relies on pathological examination and electrophysiological examination, which is easy to be missed in the early stage. Early recognition and appropriate management of small nerve fiber impairment of GBS are keys to reduce GBS mortality. In this paper, the pathogenesis, clinical manifestations, diagnosis, treatment and other aspects of small nerve fiber impairment of GBS are reviewed to provide clinicians with a comprehensive understanding of small nerve fiber impairment of GBS.
