Recent advance in role of histone H3 lysine 27 trimethylation in diagnosis and treatment of posterior fossa ependymoma and its potential targets
10.3760/cma.j.cn115354-20200325-00220
- VernacularTitle:后颅窝室管膜瘤诊疗中H3K27me3的作用及其他潜在治疗靶点的研究进展
- Author:
Guanyi WANG
1
;
Xiaosheng HE
Author Information
1. 空军军医大学西京医院神经外科，西安 710032
- Keywords:
Ependymoma;
Posterior fossa;
Histone H3 lysine 27 trimethylation;
Child;
Methylation
- From:
Chinese Journal of Neuromedicine
2020;19(6):557-561
- CountryChina
- Language:Chinese
-
Abstract:
As a kind of neuroectodermal tumor, ependymoma usually occurs in the spine in adults. However, 90% of children's ependymomas are intracranially located, and two thirds of them are located in the posterior fossa. The most commonly used clinical treatment for posterior fossa ependymomas is surgery combined with postoperative adjuvant therapy, but the high recurrence rate and poor prognosis suggest that it is urgent to explore more targeted and efficient treatment methods. In recent years, molecular biology technology has developed rapidly, the molecular biological characteristics of posterior fossa ependymomas are partially elucidated, and the molecular typing has been preliminarily determined and many potential therapeutic targets have been proposed. This review focuses on the role of histone H3 lysine 27 trimethylation in posterior fossa ependymoma and its potential therapeutic targets to provide references for treatments and follow-up researches of this disease.
