Deep vein thrombosis in aneurysmal subarachnoid hemorrhage at acute stage is associated with hyperfunction of coagulation factors
10.3760/cma.j.cn115354-20200106-00012
- VernacularTitle:动脉瘤性蛛网膜下腔出血急性期深静脉血栓形成与凝血因子功能亢进的关系研究
- Author:
Wang MIAO
1
;
Lei WANG
;
Yunbo SHI
;
Peijian YUE
;
Ke ZHAO
;
Jing JING
;
Peipei HANG
;
Lina ZHANG
;
Dongrui LI
;
Shuyu ZHANG
;
Junfang TENG
Author Information
1. 郑州大学第一附属医院神经重症科，郑州 450052
- Keywords:
Aneurysmal subarachnoid hemorrhage;
Deep venous thrombosis;
Thromboelastography;
Coagulation function
- From:
Chinese Journal of Neuromedicine
2020;19(6):576-581
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the changes of levels of coagulation factors at acute phase (within one week) of aneurysmal subarachnoid hemorrhage (aSAH) and their relations with deep venous thrombosis (DVT).Methods:Two hundred and two aSAH patients (aSAH group), admitted to our hospitals from March 2015 to March 2019, were selected in our study, and these patients were divided into a combined DVT subgroup and a uncombined DVT subgroup according to whether they were combined with DVT on the first and third d of onset. One hundred healthy physical examiners whose age and gender matched with those of aSAH group were selected as control group; one, 3, 5, and 7 d after onset, and one d after enrolling of subjects from the control group, thromboelastogram (TEG) was used to detect the R value of TEG (TEG-R) in all subjects. One, two, 3, 4, 5, 6 and 7 d after onset, color Doppler ultrasonography was used to determine whether aSAH patients had DVT.Results:A total of 73 patients (36.14%) were combined with DVT at acute stage of aSAH; 66 were with asymptomatic thrombosis and 7 with symptomatic thrombosis; 59 were with lower extremity intermuscular vein thrombosis and 14 were with intermuscular vein thrombosis. The incidence of DVT (68/73 [93.2%]) peaked on the 1 st-3 rd d of onset. The TEG-R of patients in aSAH group was statistically lower than that of the control group on the 1 st-3 rd d of onset ( P<0.05); the TEG-R of patients in aSAH group on the 1 st-3 rd d of onset was significantly lower than that on 5 th and 7 th d of onset ( P<0.05). The TEG-R of patients in combined DVT subgroup was significantly lower than that of the uncombined DVT subgroup ( P<0.05). Conclusions:Hyperfunction of coagulation factors at acute stage of aSAH is noted within one-3 d of onset; the incidence of DVT is the highest within 3 d of onset, mainly featured as asymptomatic intermuscular venous thrombosis. Whether or not aSAH would combine with DVT is associated with hyperfunction of coagulation factors.
