Recent advance in relation between porphyromonas gingivalis and Alzheimer's disease

VernacularTitle:牙龈卟啉单胞菌与阿尔茨海默病的相关性研究进展
Author: Yuqing LIANG ¹ ; Chengjun DONG ; Wenbin WU
Author Information

1. 成都中医药大学附属医院老年病科，成都　610072
Keywords: Porphyromonas gingivalis; Alzheimer's disease; Periodontitis; Gingipains
From: Chinese Journal of Neuromedicine 2020;19(5):525-527
CountryChina
Language:Chinese
Abstract: Porphyromonas gingivalis (P. gingivalis) is the main pathogen of chronic periodontitis (CP). It has been found in recent years that P. gingivalis is associated with the occurrence and development of Alzheimer's disease (AD). P. gingivalis infection may increase the risk of AD, but the pathogenesis remains unclear. In vitro and animal experiments showed that inhibition of gingipains, the main virulence factor of P. gingivalis, could reduce neurodegeneration, decrease the deposition of beta-amyloid protein and control the progression of AD. This article reviews the research progress between P. gingivalis and AD in recent years, and provides references for exploring new prevention and treatment strategies of AD.