Recent advance in biomarkers as predictors for conversion from mild cognitive impairment to Alzheimer's disease

VernacularTitle:预测轻度认知障碍向阿尔茨海默病转化的生物标志物的研究进展
Author: Shengnan QIAN ¹ ; Ming YU
Author Information

1. 江苏大学附属医院神经内科，镇江　212000
Keywords: Mild cognitive impairment; Alzheimer's disease; Biomarker
From: Chinese Journal of Neuromedicine 2020;19(5):519-524
CountryChina
Language:Chinese
Abstract: Mild cognitive impairment (MCI) is considered to be the early stage of dementia. About 10%-15% of MCI patients eventually develop dementia each year. Alzheimer's disease (AD) is the leading cause of dementia, and also the final outcome of most MCI. Early identification and intervention of MCI with high risk of conversion to AD is of great significance for controlling the progress of cognitive impairment. The author summarizes the latest research progress of core and other new biomarkers that predict the conversion of MCI to AD from levels of body fluid, imaging and genetics, to provide guidance for predicting the outcomes of MCI or early diagnoses of AD.