Effect of in utero exposure to antiepileptic drugs on fetal development and progeny neurodevelopment
10.3760/cma.j.cn115354-20191203-00716
- VernacularTitle:宫内暴露于抗癫痫药物对胎儿发育及子代神经发育的影响
- Author:
Qin HE
1
;
Bin LI
;
Hongbin SUN
Author Information
1. 四川省医学科学院 四川省人民医院神经内科，成都 610072
- Keywords:
Epilepsy;
Antiepileptic drug;
Gestation period;
Fetal malformation;
Progeny neurodevelopmental disorder
- From:
Chinese Journal of Neuromedicine
2020;19(4):427-431
- CountryChina
- Language:Chinese
-
Abstract:
Epilepsy is a common disease of the central nervous system, and about 25% of patients are women of childbearing age. Exposure to antiepileptic drugs (AEDs) during pregnancy in epileptic women may cause fetal malformations, progeny neurodevelopmental disorder and other long-term adverse effects, mostly related to drug dosages and combinations medication. Preconception counseling, adjustment therapeutic regimen, pregnancy planning and supplementing folic acid before pregnancy maybe help for fetal development and progeny neurodevelopment. This review focuses on the effect of intrauterine exposure to AEDs on fetal malformation and neural development in offspring, as well as its mechanism and coping strategies, in order to provide a reference for clinicians to fully understand the relations of AEDs with fetal malformation and progeny neurodevelopmental disorder, so as to reduce the clinical effect of intrauterine AEDs exposure on the fetus.
