Role of glucose Warburg effect in Alzheimer's disease and targeted therapy of AMP-activated protein kinase
10.3760/cma.j.cn115354-20191008-00576
- VernacularTitle:葡萄糖Warburg效应在阿尔兹海默病中的作用及AMPK的靶向治疗作用
- Author:
Bingxue ZHANG
1
;
Weilin LIU
;
Shengxiang LIANG
;
Lidian CHEN
Author Information
1. 福建中医药大学康复医学院，福州 350122
- Keywords:
Alzheimer's disease;
Glucose metabolism;
Warburg effect;
Cognitive function
- From:
Chinese Journal of Neuromedicine
2020;19(4):349-354
- CountryChina
- Language:Chinese
-
Abstract:
Brain glucose metabolism disorder is one of the pathophysiological features of Alzheimer's disease (AD), in which aerobic glycolysis (Warburg effect) metabolic pathway abnormality is one of the causes of early cognitive impairment in AD, and improving brain energy metabolism has become an important strategy to prevent AD. AMP-activated protein kinase (AMPK) is a central hub regulating glucose metabolism, the most sensitive molecular compound for sensing fluctuations of energy levels in the body. Activation of AMPK can affect the Warburg effect and its key rate-limiting enzyme activity, regulate brain glucose metabolism involved in the pathogenesis of AD, to achieve the purpose of delaying AD progression and improving cognitive function in early clinical stage. In this review, we will discuss the pathogenesis of AD and targeting of AMPK from the perspective of Warburg effect in glucose metabolism.
