Recent advance in relation between trimethylamine oxide metabolized by intestinal microbes and ischemic cerebrovascular diseases
10.3760/cma.j.cn115354-20190517-00279
- VernacularTitle:肠道菌群代谢产物氧化三甲胺与缺血性脑血管病关系的研究进展
- Author:
Caizhen LI
1
;
Chao JIANG
Author Information
1. 郑州大学第五附属医院神经内科，郑州 450052
- Keywords:
Cerebrovascular disease;
Trimethylamine oxide;
Intestinal microbe
- From:
Chinese Journal of Neuromedicine
2020;19(3):310-315
- CountryChina
- Language:Chinese
-
Abstract:
Trimethylamine oxide (TMAO) is a product of the metabolism of nutrients such as choline by intestinal microbes and liver enzymes. Recent studies have revealed that TMAO may be essential for occurrence and development of cerebrovascular diseases by disturbing the reverse transport of cholesterol, upregulating expressions of macrophage receptors associated with development of atherosclerosis, synthesis of bile acids, vascular endothelial cell inflammation, platelet aggregation and thrombosis. In this paper, we review recent studies about the production of TMAO, and efficacy of TMAO in occurrence and development of ischemic cerebrovascular diseases. This review will help us to understand TMAO related pathogenesis and pathophysiological process of ischemic cerebrovascular diseases and to identify potential therapeutic targets to facilitate translational research in this field.
